Karanjin

Karanjin is an orally active furanoflavonoid which can be isolated from several Leguminosae. Karanjin exhibits evident anti-diabetic, anti-cancer, anti-inflammatory, antioxidant, anticolitis, anti-ulcer, anti-Alzheimer properties and multiple insect repellent/insecticidal, acaricide properties, suggesting the potential of Karanjin to be applied to relevant research[1].

Product Specifications

CAS Number

[521-88-0]

UNSPSC

12352005

Hazard Statement

H302, H312, H315, H319, H332, H335

Target

AMPK; Apoptosis; Cytochrome P450; NF-κB; Phosphatase

Type

Natural Products

Related Pathways

Apoptosis; Epigenetics; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Endocrinology; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/karanjin.html

Purity

99.90

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=CC=C(OC=C3)C3=C2OC(C4=CC=CC=C4)=C1OC

Molecular Formula

C18H12O4

Molecular Weight

292.29

Precautions

H302, H312, H315, H319, H332, H335

References & Citations

[1]Guo JR, et al. Effects of karanjin on cell cycle arrest and apoptosis in human A549, HepG2 and HL-60 cancercells. Biol Res. 2015 Jul 26;48:40.|[2]Jaiswal N, et al.Karanjin from Pongamia pinnata induces GLUT4 translocation in skeletal muscle cells in a phosphatidylinositol-3-kinase-independent manner. Eur J Pharmacol. 2011 Nov 16;670 (1) :22-8.|[3]Singh A, et al. Karanjin. Phytochemistry. 2021, 183:112641.