DEN1B rabbit pAb
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]). [supplied by OMIM, Nov 2010],
Product Specifications
Background
Gene ID
163486
UniProt
Q6P3S1
Cellular Locus
Cytoplasm, cytosol. Cytoplasmic vesicle, clathrin-coated vesicle.
Host
Rabbit
Species Reactivity
Human,Mouse
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human DEN1B AA range: 325-375
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB
Validated Applications
WB
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
WB 1: 500-2000
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES16970-1.pdf
Subcellular Location
Cytoplasm, cytosol . Cytoplasmic vesicle, clathrin-coated vesicle .
Gene ID (Human)
163486
SwissProt (Human)
Q6P3S1
Available Sizes
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