Arterolane (maleate)

Arterolane (OZ 277) (maleate) is an orally active antimalarial. Arterolane exhibits potent activity against erythrocytic stages of P. falciparum and Plasmodium vivax. Arterolane (maleate) is promising for research of falciparum malaria[1][2].

Product Specifications

CAS Number

[959520-73-1]

Product Name Alternative

OZ 277 (maleate) ; RBx 11160 (maleate)

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/arterolane-maleate.html

Smiles

O=C(NCC(N)(C)C)C[C@H](CC1)CC[C@]21OO[C@]3(O2)[C@H]4C[C@@H]5C[C@H](C4)C[C@H]3C5.O=C(O)/C=C\C(O)=O

Molecular Formula

C26H40N2O8

Molecular Weight

508.60

References & Citations

[1]Toure OA, et al. A Phase 3, Double-Blind, Randomized Study of Arterolane Maleate-Piperaquine Phosphate vs Artemether-Lumefantrine for Falciparum Malaria in Adolescent and Adult Patients in Asia and Africa. Clin Infect Dis. 2016 Apr 15;62 (8) :964-971. |[2]Toure OA, et al. Efficacy and safety of fixed dose combination of arterolane maleate and piperaquine phosphate dispersible tablets in paediatric patients with acute uncomplicated Plasmodium falciparum malaria: a phase II, multicentric, open-label study. Malar J. 2015 Nov 25;14:469.