Policresulen

Policresulen is a competitive inhibitor for DENV2 NS2B/NS3 protease with an IC50 of 0.48 μg/mL. Policresulen can be used as a local hemostatic and antibacterial agent for research of cervical and vaginal inflammation, skin lesions, oral mucosa and gingival inflammation[1][2].

Product Specifications

CAS Number

[101418-00-2]

UNSPSC

12352100

Hazard Statement

H302, H315, H319, H335

Target

Dengue Virus; Virus Protease

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/policresulen.html

Purity

51.6

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

CC1=C(C)C(O)=C(S(=O)(O)=O)C=C1CC.[n]

Molecular Formula

(C8H10O4S) n

Precautions

H302, H315, H319, H335

References & Citations

[1]Wu DW, et al. Policresulen, a novel NS2B/NS3 protease inhibitor, effectively inhibits the replication of DENV2 virus in BHK-21 cells. Acta Pharmacol Sin. 2015;36 (9) :1126-1136. |[2]Zaher A R, et al. Immunohistochemical Expression Of Epithelial Cadherin In The Buccal Mucosa Of Guinea Pigs After Topical Application Of Policresulen[J]. Cairo Dental Journal, 2014, 20: 17-21.