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5'-Guanidinonaltrindole (hydrochloride)

Product Specifications

UNSPSC Description

5'-Guanidinonaltrindole (5'-GNTI) hydrochloride is a highly selective and potent κ-opioid receptor antagonist with a Ki of 0.18 nM for human κ-opioid receptor[1].

Target Antigen

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein;Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/5-guanidinonaltrindole-hydrochloride.html

Purity

98.72

Solubility

DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 25 mg/mL (ultrasonic)

Smiles

NC(NC1=CC2=C(NC3=C2C[C@]([C@]4([H])N(CC5CC5)CC6)(O)[C@]76[C@@]3([H])OC8=C(O)C=CC(C4)=C87)C=C1)=N.[H]Cl.[H]Cl

Molecular Weight

544.47

References & Citations

[1]Jones R M, et al. 5′-Guanidinonaltrindole, a highly selective and potent κ-opioid receptor antagonist. European journal of pharmacology, 2000, 396(1): 49-52.|[2]Cowan A, et al. Itching-like behavior: A common effect of the kappa opioid receptor antagonist 5′-guanidinonaltrindole and the biased kappa opioid receptor agonist 6′-guanidinonaltrindole in mice. Medicine in Drug Discovery, 2021, 11: 100097.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-107748/5-Guanidinonaltrindole-hydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-107748/5-Guanidinonaltrindole-hydrochloride-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

351183-88-5

Available Sizes

Curated Selection

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