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NKG2A-CD94 Heterodimer, Mouse (HEK293, mFc)

NKG2A Protein, a crucial immune inhibitory receptor, forms a complex with KLRD1 on lymphocyte subsets for self-nonself discrimination. Recognizing HLA-E loaded with self-peptides, it monitors MHC class I expression in healthy cells, promoting self-tolerance. NKG2A transmits signals through ITIMs, recruiting tyrosine phosphatases to counteractivate receptors. As a key inhibitor on NK cells, it regulates their functions, distinguishing harmless from pathogenic antigens. In the tumor microenvironment, NKG2A acts as an immune inhibitory checkpoint, contributing to cell exhaustion. During viral infection, it inhibits NK cell cytotoxicity, facilitating viral immune escape. NKG2A-CD94 Heterodimer Protein, Mouse (HEK293, mFc) is a recombinant protein dimer complex containing mouse-derived NKG2A-CD94 Heterodimer protein, expressed by HEK293 , with C-mFc labeled tag. NKG2A-CD94 Heterodimer Protein, Mouse (HEK293, mFc), has molecular weight of 58-68 kDa.

Product Specifications

Product Name Alternative

NKG2A-CD94 Heterodimer Protein, Mouse (HEK293, mFc), Mouse, HEK293

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/nkg2a-cd94-heterodimer-protein-mouse-hek293-mfc.html

Purity

95.0

Molecular Formula

/&16643 (Gene_ID) Q9WU31 (N98-I244) &O54707 (I32-I179) (Accession)

Molecular Weight

58-68 kDa

References & Citations

[1]Braud VM, et al. HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. Nature. 1998 Feb 19;391 (6669) :795-9.|[2]Kabat J, et al. Role that each NKG2A immunoreceptor tyrosine-based inhibitory motif plays in mediating the human CD94/NKG2A inhibitory signal. J Immunol. 2002 Aug 15;169 (4) :1948-58.|[3]Jabri B, et al. TCR specificity dictates CD94/NKG2A expression by human CTL. Immunity. 2002 Oct;17 (4) :487-99.|[4]Kamiya T, et al. Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells. J Clin Invest. 2019 Mar 12;129 (5) :2094-2106.

Shipping Conditions

Room temperature in continental US; may vary elsewhere.

Storage Conditions

Stored at -20°C for 2 years

Scientific Category

Recombinant Proteins

Available Sizes

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