PGD97
PGD97 is a selective cyclic peptide inhibitor against CAL/CFTR interactions, with a KD value of 6 nM towards the CAL PDZ domain for its desulfide cyclized form. PGD97 (desulfide cyclized form) has selectivity ≥ 130-fold compared to NHERF1/2 PDZ domains. PGD97 is capable of stabilizing F508del-CFTR at the cell membrane and improving CFTR function required for proper fluid homeostasis in tne lung. PGD97 can be used for the research of cystic fibrosis[1].
Product Specifications
CAS Number
2717490-36-1
UNSPSC
12352209
Target
CFTR; Chloride Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/pgd97.html
Smiles
O=C(N1[C@](CCCC1)([H])C(N[C@@H](C(C)(SSC[C@@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2)=O)CC3=CC4=C(C=CC=C4)C=C3)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)NC(C)=O)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)C(C)(C)C)=O)=O)=O)=O)[C@@H]2CC5=CSC6=CC=CC=C56
Molecular Formula
C74H111N23O14S3
Molecular Weight
1643.01
References & Citations
[1]Dougherty PG, et al. Cyclic Peptidyl Inhibitors against CAL/CFTR Interaction for Treatment of Cystic Fibrosis. J Med Chem. 2020, 63 (24) :15773-15784.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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