GHBP Human (Highly Pure, Lyophilized)

<strong>GHBP Human (Highly Pure)</strong>_x000D_ <strong>Catalog number:</strong> B2010435_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 50 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> 28.1 kDa_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Appearance:</strong> Powder_x000D_ <strong>Applications:</strong> Highly pure human GHBP. This protein acts as a transmembrane receptor for growth hormone._x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> Somatotropin receptor, GH receptor, GHR, GHBP_x000D_ <strong>Grade:</strong> Biotechnology grade. All solid components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Hansen TK, Fisker S, Hansen B, Sørensen HH, Christiansen JS, Jørgensen JO,_x000D_ ØRskov H. Impact of GHBP interference on estimates of GH and GH_x000D_ pharmacokinetics. Clin Endocrinol (Oxf). 2002 Dec;57(6):779-86._x000D_ _x000D_ 2: Mullis PE, Eblé A, Wagner JK, Holl RW, Silbergeld A, Laron Z. Effect of_x000D_ different serum concentrations of growth hormone-binding protein (GHBP) on the_x000D_ regulation of GH receptor/GHBP gene transcription in a human hepatoma cell line._x000D_ Horm Res. 1997;47(2):73-80._x000D_ _x000D_ 3: De Vries WR, Koppeschaar HP, Bol E, Roelen CA, Donker GH, Doerga ME, Osman-_x000D_ Dualeh M, Snel YE. Intersubject responsiveness of high-affinity growth hormone_x000D_ (GH)-binding protein (GH_BP) to long-term GH replacement therapy. J Endocrinol_x000D_ Invest. 2000 Jul-Aug;23(7):449-56._x000D_ _x000D_ 4: Davis SL, Wehr NB, Laird DM, Hammond AC. Serum growth hormone-binding protein_x000D_ (GHBP) in domestic animals as measured by ELISA. J Anim Sci. 1994_x000D_ Jul;72(7):1719-27._x000D_ _x000D_ 5: Schilbach K, Bidlingmaier M. Growth hormone binding protein - physiological_x000D_ and analytical aspects. Best Pract Res Clin Endocrinol Metab. 2015_x000D_ Oct;29(5):671-83._x000D_ _x000D_ 6: Fusco A, Miele L, D'Uonnolo A, Forgione A, Riccardi L, Cefalo C, Barini A,_x000D_ Bianchi A, Giampietro A, Cimino V, Landolfi R, Grieco A, De Marinis L._x000D_ Nonalcoholic fatty liver disease is associated with increased GH_BP and reduced_x000D_ GH/IGF-I levels. Clin Endocrinol (Oxf). 2012 Oct;77(4):531-6._x000D_ _x000D_ 7: Zhang Y, Jiang J, Black RA, Baumann G, Frank SJ. Tumor necrosis factor-alpha_x000D_ converting enzyme (TACE) is a growth hormone binding protein (GH_BP) sheddase:_x000D_ the metalloprotease TACE/ADAM-17 is critical for (PMA-induced) GH receptor_x000D_ proteolysis and GHBP generation. Endocrinology. 2000 Dec;141(12):4342-8._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/9426380/">8: Kratzsch J, Dehmel B, Pulzer F, Keller E, Englaro P, Blum WF, Wabitsch M._x000D_ Increased serum GHBP levels in obese pubertal children and adolescents:_x000D_ relationship to body composition, leptin and indicators of metabolic_x000D_ disturbances. Int J Obes Relat Metab Disord. 1997 Dec;21(12):1130-6. </a>_x000D_ _x000D_ <strong>Products Related to GHBP Human (Highly Pure) </strong> <a href="https://moleculardepot.com/product-category/Proteins/">: Proteins</a>