Boc-C14-COOH

Boc-C14-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Boc-C14-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

Product Specifications

CAS Number

[843666-27-3]

UNSPSC

12352203

Hazard Statement

H302, H312, H332

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/boc-c14-cooh.html

Purity

98.0

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(O)CCCCCCCCCCCCCCC(OC(C)(C)C)=O

Molecular Formula

C20H38O4

Molecular Weight

342.51

Precautions

H302, H312, H332

References & Citations

[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16 (5) :315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.