ADAMTS-5-IN-2
ADAMTS-5-IN-2 (compound 25) is a potent ADAMTS-5 inhibitor with an IC50 value of 0.71 µM. ADAMTS-5-IN-2 has the potential for the research of modifying osteoarthritis[1][2].
Product Specifications
CAS Number
294648-66-1
UNSPSC
12352005
Target
ADAMTS
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/adamts-5-in-2.html
Purity
98.73
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NC2=C(C=C(CC)C=C2)C13SC(C4=CC=CC=C4)=NN3
Molecular Formula
C17H15N3OS
Molecular Weight
309.39
References & Citations
[1]Bompiani KM, et al. High-Throughput Screening Uncovers Novel Botulinum Neurotoxin Inhibitor Chemotypes. ACS Comb Sci. 2016 Aug 8;18 (8) :461-74.|[2]Matthew G. Bursavich; et al. 5′-Phenyl-3′H-spiro[indoline-3,2′-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (Aggrecanase-2) . Bioorganic & Medicinal Chemistry Letters. 2007, 17 (20), 5630-5633.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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