Monomethyl auristatin E intermediate-14

Monomethyl auristatin E intermediate-14 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162) . Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs) [1].

Product Specifications

CAS Number

[1932791-56-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ADC Payload

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/monomethyl-auristatin-e-intermediate-14.html

Purity

98.55

Solubility

10 mM in DMSO

Smiles

CC[C@H](C)[C@H](C(O)=O)NCC1=CC=CC=C1

Molecular Formula

C13H19NO2

Molecular Weight

221.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75 (7) :1376-87.