PI3Kα-IN-1
PI3Kα-IN-1 is a PI3Kα inhibitor (IC50 IC50: 104 nM) [1].
Product Specifications
CAS Number
2100855-80-7
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi3kα-in-1.html
Solubility
10 mM in DMSO
Smiles
CC(NC1=CC=C(NC(NC2=CC=C(C3=NC(N4CCOCC4)=C5C(C=CC=N5)=N3)C=C2)=O)C=C1)=O
Molecular Formula
C26H25N7O3
Molecular Weight
483.52
References & Citations
[1]Al-Ashmawy AAK, et al. Design, synthesis and SAR of new-di-substituted pyridopyrimidines as ATP-competitive dual PI3Kα/mTOR inhibitors. Bioorg Med Chem Lett. 2017 Jul 15;27 (14) :3117-3122.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα
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