Cyclo (Arg-Gly-Asp- (D-Phe) -Glu)

Cyclo (Arg-Gly-Asp- (D-Phe) -Glu) c (RGDfE) is a cyclic RGD peptide targeting integrin αvβ3. Cyclo (Arg-Gly-Asp- (D-Phe) -Glu) is commonly used for modifying drug loaded nanoparticles. Cyclo (Arg-Gly-Asp- (D-Phe) -Glu) is often used in cancer research, such as pancreatic cancer[1][2].

Product Specifications

CAS Number

[756500-22-8]

Product Name Alternative

C (RGDfE)

UNSPSC

12352209

Target

Integrin

Type

Peptides

Related Pathways

Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cyclo-arg-gly-asp-d-phe-glu.html

Purity

99.86

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

O=C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N1)=O)CC(O)=O)=O)=O)CCCNC(N)=N)=O)CCC(O)=O)[C@H]1CC2=CC=CC=C2

Molecular Formula

C26H36N8O9

Molecular Weight

604.61

References & Citations

[1]Kim DH, et al. Deoxycholate bile acid directed synthesis of branched Au nanostructures for near infrared photothermal ablation. Biomaterials. 2015 Jul;56:154-64.|[2]Sun J , et al. A c (RGDfE) conjugated multi-functional nanomedicine delivery system for targeted pancreatic cancer therapy. J Mater Chem B. 2015 Feb 14;3 (6) :1049-1058.