Darolutamide
Darolutamide (ODM-201; BAY-1841788) is a potent androgen receptor (AR) antagonist with an IC50 of 26 nM in in vitro assay.
Product Specifications
CAS Number
[1297538-32-9]
Product Name Alternative
ODM-201; BAY-1841788
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ODM-201.html
Purity
99.73
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=C(C#N)C=CC(C2=NN(C[C@H](C)NC(C3=NNC(C(O)C)=C3)=O)C=C2)=C1
Molecular Formula
C19H19ClN6O2
Molecular Weight
398.85
Precautions
H302, H315, H319, H335
References & Citations
[1]Moilanen AM, et al. Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms toandrogen signaling-directed prostate cancer therapies. Sci Rep. 2015 Jul 3;5:12007. doi: 10.1038/srep12007.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Curated Selection
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