N6,2′-O-Dimethyladenosine

N6,2′-O-Dimethyladenosine is a substrate of fat mass and obesity-associated gene (FTO) and mRNA cap modification. N6,2′-O-Dimethyladenosine dynamically regulates mRNA stability, translation efficiency, and protein expression. N6,2′-O-Dimethyladenosine can regulate obesity[1][2].

Product Specifications

CAS Number

[57817-83-1]

UNSPSC

12352005

Target

Fat Mass and Obesity-associated Protein (FTO)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/n6-2-o-dimethyladenosine.html

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O[C@H]1[C@@H](OC)[C@H](N2C(N=CN=C3NC)=C3N=C2)O[C@@H]1CO

Molecular Formula

C12H17N5O4

Molecular Weight

295.29

References & Citations

[1]Ben-Haim MS, et, al. Dynamic regulation of N 6,2'-O-dimethyladenosine (m 6 Am) in obesity. Nat Commun. 2021 Dec 10;12 (1) :7185.|[2]Jiang J, et, al. m6AmPred: Identifying RNA N6, 2'-O-dimethyladenosine (m 6 A m) sites based on sequence-derived information. Methods. 2021 Feb 2; S1046-2023 (21) 00019-0.