BET-IN-14

BET-IN-14 is an orally active pan BET inhibitor (IC50: 5.35 nM) . BET-IN-14 has anti-cancer activity[1].

Product Specifications

CAS Number

[2243669-93-2]

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bet-in-14.html

Purity

99.07

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=CC=C(N2C(C3=CC(N(C4CCCC4)[C@H](C)C(N5C)=O)=C5C=C3)=NC(C(N6CCN(C)CC6)=O)=N2)C=C1

Molecular Formula

C30H37N7O2

Molecular Weight

527.66

References & Citations

[1]Damaneh MS, et al. A new BET inhibitor, 171, inhibits tumor growth through cell proliferation inhibition more than apoptosis induction. Invest New Drugs. 2020 Jun;38 (3) :700-713.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

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