BET-IN-14
BET-IN-14 is an orally active pan BET inhibitor (IC50: 5.35 nM) . BET-IN-14 has anti-cancer activity[1].
Product Specifications
CAS Number
[2243669-93-2]
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bet-in-14.html
Purity
99.07
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC=C(N2C(C3=CC(N(C4CCCC4)[C@H](C)C(N5C)=O)=C5C=C3)=NC(C(N6CCN(C)CC6)=O)=N2)C=C1
Molecular Formula
C30H37N7O2
Molecular Weight
527.66
References & Citations
[1]Damaneh MS, et al. A new BET inhibitor, 171, inhibits tumor growth through cell proliferation inhibition more than apoptosis induction. Invest New Drugs. 2020 Jun;38 (3) :700-713.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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