Norisoboldine (hydrochloride)

Norisoboldine hydrochloride is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine hydrochloride, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis[1][2].

Product Specifications

CAS Number

[5083-84-1]

Product Name Alternative

(+) -Laurelliptine hydrochloride

UNSPSC

12352005

Target

Adenosine Receptor

Type

Natural Products

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/norisoboldine-hydrochloride.html

Purity

99.72

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[H]Cl.OC1=C(OC)C=C2CCN[C@@]3([H])CC4=CC(O)=C(OC)C=C4C1=C23

Molecular Formula

C18H20ClNO4

Molecular Weight

349.81

References & Citations

[1]Luo Y, et al. Therapeutic effect of norisoboldine, an alkaloid isolated from Radix Linderae, on collagen-induced arthritis in mice. Phytomedicine. 2010;17 (10) :726-731.|[2]Lv Q, et al. Norisoboldine, a natural AhR agonist, promotes Treg differentiation and attenuates colitis via targeting glycolysis and subsequent NAD+/SIRT1/SUV39H1/H3K9me3 signaling pathway. Cell Death Dis. 2018;9 (3) :258. Published 2018 Feb 15.