Calcifediol (monohydrate)

Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels[1][2][3].

Product Specifications

CAS Number

[63283-36-3]

Product Name Alternative

25-hydroxy Vitamin D3 (monohydrate)

UNSPSC

12352211

Hazard Statement

H300+H310+H330, H372

Target

Endogenous Metabolite; VD/VDR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Metabolic Disease

Purity

99.98

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C=C(CC1)/C(C[C@H]1O)=C\C=C2[C@@]3([H])[C@@](CCC\2)(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC3.O

Molecular Formula

C27H46O3

Molecular Weight

418.65

Precautions

H300+H310+H330, H372

References & Citations

[1]Castoldi A, et al. Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. Eur J Pharm Biopharm. 2016 Nov 22.|[2]Wei Zheng, et al. Vitamin D-induced vitamin D receptor expression induces tamoxifen sensitivity in MCF-7 stem cells via suppression of Wnt/β-catenin signaling. Biosci Rep. 2018 Dec 7;38 (6) :BSR20180595.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

Human Endogenous Metabolite

Citation 01

Sci Rep. 2022 Feb 22;12 (1) :3014.|Front Pharmacol. 2020 Mar 31;11:200.|Int Immunopharmacol. 2023 Sep:122:110558.|Int J Mol Sci. 2017 Dec 19;18 (12) . pii: E2764.|Int J Mol Sci. 2025 Mar 25;26 (7) :2985.|J Sep Sci. 2025 Apr;48 (4) :e70130.|Nat Chem Biol. 2022 Nov;18 (11) :1196-1203.|Proc Natl Acad Sci U S A. 2022 Apr 12;119 (15) :e2117004119.|Ther Adv Endocrinol Metab. 2020 Oct 20:11:2042018820958295.|Virol Sin. 2024 Aug 19:S1995-820X (24) 00134-2.