Lavendustin B

Lavendustin B is an inhibitor of HIV-1 integrase interaction with LEDGF/p75 with an IC50 of 94.07 μM. Lavendustin B is an ATP-competitive GLUT1 inhibitor with a Ki of 15 μM. Lavendustin B is also a weak inhibitor of tyrosine kinases[1][2].

Product Specifications

CAS Number

[125697-91-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GLUT; HIV Integrase; Tyrosinase

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lavendustin-b.html

Purity

98.02

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC(N(CC2=CC=CC=C2O)CC3=CC=CC=C3O)=CC=C1O

Molecular Formula

C21H19NO5

Molecular Weight

365.38

Precautions

H302, H315, H319, H335

References & Citations

[1]J C Vera, et al. Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors. Biochemistry. 2001 Jan 23;40 (3) :777-90.|[2]Fatima E Agharbaoui, et al. Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase. Eur J Med Chem. 2016 Nov 10;123:673-683.