MS154N

MS154N (compound 28) is the negative control of MS39 (HY-157581) . MS154N is composed of PROTAC target protein ligand EGFR ligand-11 (HY-168305) (red part), E3 ligase ligand 4-Hydroxy-2- (1-methyl-2,6-dioxopiperidin-3-yl) isoindoline-1,3-dione (HY-W441376) (blue part) and PROTAC Linker 8-Iodooctan-1-amine (HY-168306) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is Me-Thalidomide-O-C8-NH2 (HY-168307) [1].

Product Specifications

CAS Number

[2675490-97-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

EGFR; PROTACs

Type

Reference compound

Related Pathways

JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ms154n.html

Purity

99.30

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(C(N1C3C(N(C)C(CC3)=O)=O)=O)C(OCCCCCCCCNC(CCN4CCN(CCCOC5=CC6=C(NC7=CC=C(C(Cl)=C7)F)N=CN=C6C=C5OC)CC4)=O)=CC=C2

Molecular Formula

C47H56ClFN8O8

Molecular Weight

915.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Cheng M, et al. Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders. J Med Chem. 2020 Feb 13;63 (3) :1216-1232.