KRAS G12D inhibitor 14
Product Specifications
UNSPSC Description
KRAS G12D inhibitor 14 is a potent KRAS G12D inhibitor with a KD of 33 nM for binding to KRAS G12D protein. KRAS G12D inhibitor 14 decreases the active form of KRAS G12D (KRAS G12D-GTP) but not KRAS G13D[1].
Target Antigen
Apoptosis; Ras
Type
Reference compound
Related Pathways
Apoptosis;GPCR/G Protein;MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kras-g12d-inhibitor-14.html
Solubility
DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
COC1=CC=C(C=C1C2=CC3=C(N=CN=C3S2)N4CC5CCC4CN5)C(F)(F)F
Molecular Weight
420.45
References & Citations
[1]Li L, et al. Discovery of Thieno[2,3-d]pyrimidine-based KRAS G12D inhibitors as potential anticancer agents via combinatorial virtual screening. Eur J Med Chem. 2022;233:114243.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-144661/KRAS-G12D-inhibitor-14-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-144661/KRAS-G12D-inhibitor-14-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2765254-39-3
Available Sizes
Curated Selection
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