HDAC6-IN-51

HDAC6-IN-51 (Compound 7e) is a selective HDAC6 inhibitor with an IC50 value of 42.9 nM. HDAC6-IN-51 exhibits good anti-lung fibrosis activity[1].

Product Specifications

CAS Number

[2994634-78-3]

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hdac6-in-51.html

Smiles

O=C(C1=CC=C(C=C1)CN2C(C3=C(N4CCN=C24)CCN(C3)CC5=CC(Cl)=CC=C5)=O)NO

Molecular Formula

C24H24ClN5O3

Molecular Weight

465.93

References & Citations

[1]Gao Y, et al. Design, synthesis, and evaluation of a novel TRAIL-activated HDAC6 inhibitor for the treatment of pulmonary fibrosis[J]. Bioorganic & Medicinal Chemistry, 2024, 113: 117924.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HDAC2; HDAC3; HDAC6; HDAC8

Curated Selection

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