HDAC6-IN-51
HDAC6-IN-51 (Compound 7e) is a selective HDAC6 inhibitor with an IC50 value of 42.9 nM. HDAC6-IN-51 exhibits good anti-lung fibrosis activity[1].
Product Specifications
CAS Number
[2994634-78-3]
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hdac6-in-51.html
Smiles
O=C(C1=CC=C(C=C1)CN2C(C3=C(N4CCN=C24)CCN(C3)CC5=CC(Cl)=CC=C5)=O)NO
Molecular Formula
C24H24ClN5O3
Molecular Weight
465.93
References & Citations
[1]Gao Y, et al. Design, synthesis, and evaluation of a novel TRAIL-activated HDAC6 inhibitor for the treatment of pulmonary fibrosis[J]. Bioorganic & Medicinal Chemistry, 2024, 113: 117924.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC2; HDAC3; HDAC6; HDAC8
Curated Selection
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