HSP90-IN-30

HSP90-IN-30 (compound 3e) inhibits HSP90 chaperone activity. HSP90-IN-30 inhibits the activity of HIF-1 transcriptional under hypoxia with an IC50 value of 2.16 μM[1].

Product Specifications

UNSPSC

12352005

Target

HIF/HIF Prolyl-Hydroxylase; HSP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hsp90-in-30.html

Solubility

10 mM in DMSO

Smiles

CC(C)CC(CC[BH]1234[B]567(C8=C(C(NC(C)C)=O)N(CC9=CC=CC=C9)N=N8)[BH]1%10%11[BH]5%12%13[BH]6%14%15[BH]72%16[BH]%14%17%18[BH]%15%12%19[BH]%10%13%20[BH]%113%21[BH]%164%17[BH]%20%21%19%18)=O

Molecular Formula

C20H39B12N4O2

Molecular Weight

497.28

References & Citations

[1]Yujie Shao, et al. Discovery of Disubstituted Carboranes as Inhibitors of Heat Shock Protein 90–Heat Shock Factor 1 Interaction. ACS Med. Chem. Lett. 2024.