PROTAC BRD9 Degrader-1
PROTAC BRD9 Degrader-1 is a PROTAC connected by ligands for Cereblon and BRD9 (IC50=13.5 nM), which can be used as a selective probe useful for the study of BAF complex biology[1].
Product Specifications
CAS Number
2097971-01-0
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PROTAC_BRD9_Degrader-1.html
Purity
99.16
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1C(C=C(C(NC(CC2)CCS2(=O)=O)=N)S3)=C3C(C4=CC(OC)=C(OCC(NCCCCNC(COC5=C(C(N6C(CCC7=O)C(N7)=O)=O)C(C6=O)=CC=C5)=O)=O)C=C4)=CN1C
Molecular Formula
C42H45N7O12S2
Molecular Weight
903.98
Precautions
H315, H319, H320
References & Citations
[1]Remillard D, et al. Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands. Angew Chem Int Ed Engl. 2017 May 15;56 (21) :5738-5743.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4; BRD9; Cereblon
Available Sizes
Frequently Asked Questions
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