PROTAC BRD9 Degrader-1

PROTAC BRD9 Degrader-1 is a PROTAC connected by ligands for Cereblon and BRD9 (IC50=13.5 nM), which can be used as a selective probe useful for the study of BAF complex biology[1].

Product Specifications

CAS Number

[2097971-01-0]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Epigenetic Reader Domain; PROTACs

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PROTAC_BRD9_Degrader-1.html

Purity

99.16

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C1C(C=C(C(NC(CC2)CCS2(=O)=O)=N)S3)=C3C(C4=CC(OC)=C(OCC(NCCCCNC(COC5=C(C(N6C(CCC7=O)C(N7)=O)=O)C(C6=O)=CC=C5)=O)=O)C=C4)=CN1C

Molecular Formula

C42H45N7O12S2

Molecular Weight

903.98

Precautions

H315, H319, H320

References & Citations

[1]Remillard D, et al. Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands. Angew Chem Int Ed Engl. 2017 May 15;56 (21) :5738-5743.