SB-431542 (GMP)
SB-431542 (GMP) is SB-431542 produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SB-431542 is a TGF-β receptor kinase inhibitor (TRKI) in SMAD signaling[1][2][3].
Product Specifications
CAS Number
301836-41-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
TGF-β Receptor
Type
GMP Small Molecules
Related Pathways
TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sb-431542-gmp.html
Purity
100.2
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(C=C1)C2=NC(C3=CC=C4OCOC4=C3)=C(N2)C5=NC=CC=C5)N
Molecular Formula
C22H16N4O3
Molecular Weight
384.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Yuchen Qi, et al. Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells. Nat Biotechnol. 2017 Feb;35 (2) :154-163.|[2]Tae Wan Kim, et al. Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use. Cell Stem Cell. 2021 Feb 4;28 (2) :343-355.e5.|[3]Monica Nafria, et al. Protocol for the Generation of Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells. STAR Protoc. 2020 Oct 16;1 (3) :100130.
Shipping Conditions
Dry Ice
Storage Conditions
-20°C, sealed storage, away from moisture and light
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported
Isoform
ALK4; ALK5; ALK7
Available Sizes
Frequently Asked Questions
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