SB-431542 (GMP)

SB-431542 (GMP) is SB-431542 (HY-10431) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SB-431542 is a TGF-β receptor kinase inhibitor (TRKI) in SMAD signaling[1][2][3].

Product Specifications

CAS Number

[301836-41-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

TGF-β Receptor

Type

GMP Small Molecules

Related Pathways

TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sb-431542-gmp.html

Purity

100.2

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C(C=C1)C2=NC(C3=CC=C4OCOC4=C3)=C(N2)C5=NC=CC=C5)N

Molecular Formula

C22H16N4O3

Molecular Weight

384.39

Precautions

H302, H315, H319, H335

References & Citations

[1]Yuchen Qi, et al. Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells. Nat Biotechnol. 2017 Feb;35 (2) :154-163.|[2]Tae Wan Kim, et al. Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use. Cell Stem Cell. 2021 Feb 4;28 (2) :343-355.e5.|[3]Monica Nafria, et al. Protocol for the Generation of Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells. STAR Protoc. 2020 Oct 16;1 (3) :100130.