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IM-12

IM-12 is an inhibitor of GSK-3β, with an IC50 of 53 nM, and also enhances Wnt signalling.

Product Specifications

CAS Number

1129669-05-1

UNSPSC

12352005

Hazard Statement

H301, H311, H331, H341

Target

GSK-3; Wnt

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/IM-12.html

Purity

99.61

Solubility

DMSO : ≥ 54.9 mg/mL

Smiles

O=C(C(NCCC1=CC=C(F)C=C1)=C2C3=C(C)NC4=C3C=CC=C4)N(C)C2=O

Molecular Formula

C22H20FN3O2

Molecular Weight

377.41

Precautions

H301, H311, H331, H341

References & Citations

[1]Schmole AC, et al. Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells. Bioorg Med Chem. 2010 Sep 15;18 (18) :6785-95.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

GSK-3β

Available Sizes

Frequently Asked Questions

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