IM-12
IM-12 is an inhibitor of GSK-3β, with an IC50 of 53 nM, and also enhances Wnt signalling.
Product Specifications
CAS Number
[1129669-05-1]
UNSPSC
12352005
Hazard Statement
H301, H311, H331, H341
Target
GSK-3; Wnt
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/IM-12.html
Purity
99.61
Solubility
DMSO : ≥ 54.9 mg/mL
Smiles
O=C(C(NCCC1=CC=C(F)C=C1)=C2C3=C(C)NC4=C3C=CC=C4)N(C)C2=O
Molecular Formula
C22H20FN3O2
Molecular Weight
377.41
Precautions
H301, H311, H331, H341
References & Citations
[1]Schmole AC, et al. Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells. Bioorg Med Chem. 2010 Sep 15;18 (18) :6785-95.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3β
Available Sizes
Curated Selection
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