Demeclocycline (hydrochloride)

Demeclocycline hydrochloride is an orally active tetracycline antibiotic that inhibits the binding of aminoacyl tRNA by binding to the 30S ribosomal subunit, thereby affecting protein synthesis. Demeclocycline hydrochloride exhibits antibacterial activity against a broad spectrum of bacterial infections[1][2].

Product Specifications

CAS Number

[64-73-3]

UNSPSC

12352005

Hazard Statement

H302+H312+H332, H315, H319, H335, H341

Target

Antibiotic; Bacterial

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/demeclocycline-hydrochloride.html

Purity

95.15

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic)

Smiles

O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2([H])C[C@]3([H])[C@H](O)C4=C(C(C3=C(O)[C@@]21O)=O)C(O)=CC=C4Cl)N.Cl

Molecular Formula

C21H22Cl2N2O8

Molecular Weight

501.31

Precautions

H302+H312+H332, H315, H319, H335, H341

References & Citations

[1]I Chopra, et al. Tetracyclines, molecular and clinical aspects. J Antimicrob Chemother. 1992 Mar;29 (3) :245-77. |[2]D Schnappinger, et al. Tetracyclines: antibiotic action, uptake, and resistance mechanisms. Arch Microbiol. 1996 Jun;165 (6) :359-69. |[3]Marleen L A Kortenoeven, et al. Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla. Am J Physiol Renal Physiol. 2013 Dec 15;305 (12) :F1705-18. |[4]Susobhan Sarkar, et al. Demeclocycline Reduces the Growth of Human Brain Tumor-Initiating Cells: Direct Activity and Through Monocytes. Front Immunol. 2020 Feb 21;11:272.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Natural Products

Clinical Information

Launched

Isoform

Tetracycline

Citation 01

Chemosphere. 2019 Jun:225:378-387.|Mol Syst Biol. 2022 Sep;18 (9) :e11081.|Patent. US20230014181.|J Hazard Mater Adv. 2025 Nov 12;20:100939.|J Photoch Photobio A. 2020 May.