Sp-8-Br-cGMPS

Sp-8-Br-cGMPS is an analog of cGMP. Sp-8-Br-cGMPS is an agonist for cGMP-gated cation channels (CNG channels), with an EC50 of 106.5 μM. Sp-8-Br-cGMPS induces the currents, without the ability to stabilize the channel open state as a full agonist[1].

Product Specifications

CAS Number

[153660-03-8]

UNSPSC

12352005

Target

HCN Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sp-8-br-cgmps.html

Smiles

O=C(NC(N)=N1)C2=C1N(C(Br)=N2)[C@H]3[C@H](O)[C@H](O[P@]4(S)=O)[C@@H](CO4)O3

Molecular Formula

C10H11BrN5O6PS

Molecular Weight

440.17

References & Citations

[1]Wei JY, et al., Substituted cGMP analogs can act as selective agonists of the rod photoreceptor cGMP-gated cation channel. J Mol Neurosci. 1998 Feb;10 (1) :53-64.