NSAH
NSAH is a reversible and competitive nonnucleoside ribonucleotide reductase (RR) inhibitor, with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively[1].
Product Specifications
CAS Number
1099592-35-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsah.html
Concentration
10mM
Purity
98.45
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=CC=C1O)N/N=C/C2=C3C=CC=CC3=CC=C2O
Molecular Formula
C18H14N2O3
Molecular Weight
306.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Md Faiz Ahmad, et al. Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proc Natl Acad Sci U S A. 2017 Aug 1;114 (31) :8241-8246.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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