PKM2-IN-6

PKM2-IN-6 (compound 7d) is a potent and orally active PKM2 inhibitor with an IC50 value of 23 nM. PKM2-IN-6 induces apoptosis and cell cycle arrest at G2 phase. PKM2-IN-6 reduces the level of PKM1 and PKM2 at the mRNA level. PKM2-IN-6 shows anticancer activity and has the potential for the research of triple-negative breast cancer[1].

Product Specifications

CAS Number

[771467-00-6]

UNSPSC

12352005

Target

Apoptosis; Pyruvate Kinase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pkm2-in-6.html

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=CC=CC=C1NC2=NC(C3=CN=C4C=CC=CN43)=CS2

Molecular Formula

C17H14N4OS

Molecular Weight

322.38

References & Citations

[1]Das R, et al. Mechanistic Investigation of Thiazole-Based Pyruvate Kinase M2 Inhibitor Causing Tumor Regression in Triple-Negative Breast Cancer. J Med Chem. 2024 Feb 26.