S1R agonist 1 (hydrochloride)

S1R agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist with Kis of 0.93 nM and 72 nM for S1R and S2R, respectively. S1R agonist 1 hydrochloride exhibits neuroprotection against ROS and NMDA-induced neurotoxicity[1].

Product Specifications

CAS Number

[242487-82-7]

UNSPSC

12352005

Target

Sigma Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s1r-agonist-1-hydrochloride.html

Concentration

10mM

Purity

99.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

[H]Cl.C1(OCCN2CCC(CC2)CC3=CC=CC=C3)=CC=CC=C1

Molecular Formula

C20H26ClNO

Molecular Weight

331.88

References & Citations

[1]Linciano P, et al. Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents. Eur J Med Chem. 2023 Mar 5;249:115163.