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VEGFR-2-IN-53

VEGFR-2-IN-53 (Compound 15w) is a VEGFR-2 inhibitor with an IC50 of 4.34 μM. VEGFR-2-IN-53 induces apoptosis by inhibiting VEGFR-2 activity and preventing cell migration, thereby exhibiting anti-angiogenic effects. The IC50 value of VEGFR-2-IN-53 for inhibiting MCF-7 cell growth is 3.87 μM. VEGFR-2-IN-53 can be used in cancer research[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; VEGFR

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vegfr-2-in-53.html

Smiles

O=C(NC1=NC2=C(C=CC=C2)S1)[C@H]3[C@H](C4=C(C)N(C5=CC=CC=C5)N=C4C)[C@@](C6=CC=CC=C6N7)3C7=O

Molecular Formula

C29H23N5O2S

Molecular Weight

505.59

References & Citations

[1]Valapil DG, et al. Design, development of pyrazole-linked spirocyclopropyl oxindole-carboxamides as potential cytotoxic agents and Type III allosteric VEGFR-2 inhibitors. ChemMedChem. 2024 Aug 1:e202400422.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

VEGFR2/KDR/Flk-1

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