BGB-102

BGB-102 is a potent multi-kinase inhibitor against EGFR, HER2, and HER4 with IC50s of 9.6 nM, 18 nM and 40.3 nM, respectively.

Product Specifications

CAS Number

[807640-87-5]

Product Name Alternative

JNJ-26483327

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/BGB-102.html

Purity

99.52

Solubility

DMSO : 4.4 mg/mL (ultrasonic) |THF : ≥ 7.27 mg/mL

Smiles

CN1CCCCCOC(C(OC)=C2)=CC3=C2N=CN/C3=N\C4=CC(Br)=CC=C4C1

Molecular Formula

C22H25BrN4O2

Molecular Weight

457.36

References & Citations

[1]Gijsen M, et al. HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer. PLoS Biol. 2010 Dec 21;8 (12) :e1000563.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

EGFR/ErbB1/HER1; ErbB2/HER2; ErbB4/HER4

Available Sizes

Curated Selection

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