PACOCF3
PACOCF3 (Palmityltrifluoromethylketone) is a selective phospholipase A2 inhibitor with an IC50 of 3.8 μM. PACOCF3 alters Ca2+ signaling in renal tubular cells[1][2].
Product Specifications
CAS Number
141022-99-3
Product Name Alternative
Palmityltrifluoromethylketone
UNSPSC
12352211
Hazard Statement
H225, H319
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pacocf3.html
Purity
99.0
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
CCCCCCCCCCCCCCCC(C(F)(F)F)=O
Molecular Formula
C17H31F3O
Molecular Weight
308.42
Precautions
H225, H319
References & Citations
[1]E J Ackermann, et al. Inhibition of macrophage Ca (2+) -independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J Biol Chem. 1995 Jan 6;270 (1) :445-50. |[2]C R Jan, et al. Dual action of palmitoyl trifluoromethyl ketone (PACOCF3) on Ca2+ signaling: activation of extracellular Ca2+ influx and alteration of ATP- and bradykinin-induced Ca2+ responses in Madin Darby canine kidney cells. Arch Toxicol. 2000 Oct;74 (8) :447-51.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Phospholipase A
Available Sizes
Frequently Asked Questions
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