α-Conotoxin AuIB (TFA)
Product Specifications
UNSPSC Description
α-Conotoxin AuIB TFA, a potent and selective α3β4 nicotinic acetylcholine receptor (nAChR) antagonist, blocks α3β4 nAChRs expressed in Xenopus oocytes with an IC50 of 0.75 μM[1].
Target Antigen
nAChR
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.37
Solubility
H2O : ≥ 100 mg/mL
Smiles
O=C(CN)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N2[C@H]3CCC2)=O)CCC1)=O)CC4=CC=C(O)C=C4)=O)CO)=O)CSSC[C@H](NC5=O)C(N)=O)=O)CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N6[C@H](C(N[C@H]5CC(O)=O)=O)CCC6)=O)CC(N)=O)=O)[C@@H](C)O)=O)C)=O)CC7=CC=CC=C7)=O.O=C(C(F)(F)F)O
Molecular Weight
1686.79
References & Citations
[1]Siqin Luo, et al. α-Conotoxin AuIB Selectively Blocks α3β4 Nicotinic Acetylcholine Receptors and Nicotine-Evoked Norepinephrine Release.Journal of Neuroscience. 1998 Nov 1, 18 (21): 8571-8579.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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