ISR-IN-1
ISR-IN-1 (Compound 48) is an inhibitor of the integrated stress response (EC50: 0.6 nM) [1].
Product Specifications
CAS Number
[1628478-15-8]
UNSPSC
12352005
Hazard Statement
H302
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/isr-in-1.html
Purity
98.92
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
FC(C=C1OCC(N[C@H](CC2)CC[C@@H]2NC(COC3=CC(F)=C(C=C3)Cl)=O)=O)=C(C=C1)Cl
Molecular Formula
C22H22Cl2F2N2O4
Molecular Weight
487.32
Precautions
H302
References & Citations
[1]Hearn BR, et al. Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response. ChemMedChem. 2016 Apr 19;11 (8) :870-80.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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