Pestanoid A
Pestanoid A is a rearranged pimarane diterpenoid osteoclastogenesis inhibitor with an IC50 of 4.2 μM. Pestanoid A can be isolated from the marine mesophotic zone chalinidae sponge-associated fungus, Pestalotiopsis sp. NBUF145. Pestanoid A inhibits the receptor activator of NF-kB ligand-induced MAPK and NF-κB signaling by suppressing the phosphorylation of ERK1/2-JNK1/2-p38 MAPKs and NF-κB nuclear translocation. Pestanoid A can be used for the study of osteoporosis[1].
Product Specifications
UNSPSC
12352005
Target
ERK; JNK; p38 MAPK
Type
Natural Products
Related Pathways
MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/pestanoid-a.html
Solubility
10 mM in DMSO
Smiles
C=C1CC[C@@]2([H])[C@@](C(C(C[C@@]3(C)[C@H](CO)OC(C3)=O)=CC(O2)=O)=O)(C)[C@@H]1C
Molecular Formula
C20H26O6
Molecular Weight
362.42
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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