Pestanoid A

Pestanoid A is a rearranged pimarane diterpenoid osteoclastogenesis inhibitor with an IC50 of 4.2 μM. Pestanoid A can be isolated from the marine mesophotic zone chalinidae sponge-associated fungus, Pestalotiopsis sp. NBUF145. Pestanoid A inhibits the receptor activator of NF-kB ligand-induced MAPK and NF-κB signaling by suppressing the phosphorylation of ERK1/2-JNK1/2-p38 MAPKs and NF-κB nuclear translocation. Pestanoid A can be used for the study of osteoporosis[1].

Product Specifications

UNSPSC

12352005

Target

ERK; JNK; p38 MAPK

Type

Natural Products

Related Pathways

MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/pestanoid-a.html

Solubility

10 mM in DMSO

Smiles

C=C1CC[C@@]2([H])[C@@](C(C(C[C@@]3(C)[C@H](CO)OC(C3)=O)=CC(O2)=O)=O)(C)[C@@H]1C

Molecular Formula

C20H26O6

Molecular Weight

362.42

References & Citations

[1]Wang T, et al. Pestanoid A, a Rearranged Pimarane Diterpenoid Osteoclastogenesis Inhibitor from a Marine Mesophotic Zone Chalinidae Sponge-Associated Fungus, Pestalotiopsis sp. NBUF145[J]. Journal of Natural Products, 2024.