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Anti-Mouse GM-CSF Antibody (MP1-22E9)

Anti-Mouse GM-CSF Antibody (MP1-22E9) is a rat-derived anti-mouse GM-CSF IgG2a antibody inhibitor. Anti-Mouse GM-CSF Antibody (MP1-22E9) can neutralize GM-CSF. Anti-Mouse GM-CSF Antibody (MP1-22E9) can be used for the researches of cancer, infection inflammation and immunology, such as cholangiocarcinoma and arthritis[1][2][3][4][5][6].

Product Specifications

CAS Number

9007-83-4

UNSPSC

12352203

Target

C-Fms

Type

Inhibitory Antibodies

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-mouse-gm-csf-antibody-mp1-22e9.html

Purity

95.00

Solubility

H2O

Smiles

[Anti-MouseGM-CSFAntibody(MP1-22E9)]

Molecular Weight

(150 kDa)

References & Citations

[1]Ruffolo LI, et al. GM-CSF drives myelopoiesis, recruitment and polarisation of tumour-associated macrophages in cholangiocarcinoma and systemic blockade facilitates antitumour immunity. Gut. 2022 Jul;71 (7) :1386-1398.|[2]Tétreault MP, et al. Esophageal Expression of Active IκB Kinase-β in Mice Up-Regulates Tumor Necrosis Factor and Granulocyte-Macrophage Colony-Stimulating Factor, Promoting Inflammation and Angiogenesis. Gastroenterology. 2016 Jun;150 (7) :1609-1619.e11.|[3]Regan-Komito D, et al. GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis. Nat Commun. 2020 Jan 9;11 (1) :155. |[4]Kim IK, et al. GM-CSF Promotes Antitumor Immunity by Inducing Th9 Cell Responses. Cancer Immunol Res. 2019 Mar;7 (3) :498-509. |[5]Horikawa N, et al. Anti-VEGF therapy resistance in ovarian cancer is caused by GM-CSF-induced myeloid-derived suppressor cell recruitment. Br J Cancer. 2020 Mar;122 (6) :778-788. |[6]McDermott AJ, et al. Role of GM-CSF in the inflammatory cytokine network that regulates neutrophil influx into the colonic mucosa during Clostridium difficile infection in mice. Gut Microbes. 2014 Jul 1;5 (4) :476-84.

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4°C, do not freeze

Scientific Category

Inhibitory Antibodies

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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