Rubratoxin A
Rubratoxin A is a natural mycotoxin and competitive inhibitor of protein phosphatase 2A (PP2A) with an IC50 of 170 nM. Rubratoxin A causes suppression of tumor metastasis and reduction of primary tumor volume in mouse xenografts[1].
Product Specifications
CAS Number
22467-31-8
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rubratoxin-a.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C2[C@H](O)[C@H]([C@H](O)CCCCCC)C3=C(C[C@H]([C@@H]([C@@H]4CC=CC(O4)=O)O)C1)C(O)OC3=O)OC2=O
Molecular Formula
C26H32O11
Molecular Weight
520.53
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Wada S, et al. Rubratoxin A specifically and potently inhibits protein phosphatase 2A and suppresses cancer metastasis. Cancer Sci. 2010 Mar;101 (3) :743-50.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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