Rubratoxin A

Rubratoxin A is a natural mycotoxin and competitive inhibitor of protein phosphatase 2A (PP2A) with an IC50 of 170 nM. Rubratoxin A causes suppression of tumor metastasis and reduction of primary tumor volume in mouse xenografts[1].

Product Specifications

CAS Number

[22467-31-8]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rubratoxin-a.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C2[C@H](O)[C@H]([C@H](O)CCCCCC)C3=C(C[C@H]([C@@H]([C@@H]4CC=CC(O4)=O)O)C1)C(O)OC3=O)OC2=O

Molecular Formula

C26H32O11

Molecular Weight

520.53

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Wada S, et al. Rubratoxin A specifically and potently inhibits protein phosphatase 2A and suppresses cancer metastasis. Cancer Sci. 2010 Mar;101 (3) :743-50.