Isosilybin B

Isosilybin B is a flavonolignan. Isosilybin B can be isolated from Silybum marianum. Isosilybin B can regulate cell cycle-related proteins (e.g., reduce cyclins (D3, D1, A, E), Cdk4, Cdk2, Cdc25A), and activate Caspases (Caspase-9 and Caspase-3) . Isosilybin B can promote Apoptosis, reduce androgen receptor (AR) and PSA. Isosilybin B has anticancer activity against prostate cancer[1][2].

Product Specifications

CAS Number

[142796-22-3]

UNSPSC

12352005

Hazard Statement

H302

Target

Androgen Receptor; Apoptosis; Caspase; CDK; PSMA

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/isosilybin-b.html

Purity

99.32

Solubility

10 mM in DMSO

Smiles

O=C1[C@H](O)[C@@H](C2=CC=C(O[C@@H](C3=CC=C(O)C(OC)=C3)[C@H](CO)O4)C4=C2)OC5=CC(O)=CC(O)=C15

Molecular Formula

C25H22O10

Molecular Weight

482.44

Precautions

H302

References & Citations

[1]Deep G, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostatecancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28 (7) :1533-42.|[2]Deep G, et al. Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway. Oncogene. 2008 Jun 26;27 (28) :3986-98.