CD22 Polyclonal Antibody

CD22, also known as Siglec-2 (sialic acid binding Ig-like lectin 2) or BL-CAM (B-lymphocyte cell adhesion molecule), is a 130-140 kDa, B-cell restricted, type I transmembrane glycoprotein belonging to the immunoglobulin gene superfamily. The expression of CD22 is developmentally regulated. It is expressed at low levels in the cytoplasm of pro-B and pre-B cells and present on the cell surface only at mature stages of B-cell differentiation. Cell surface expression is lost during terminal differentiation into plasma cell and after B-cell activation. CD22 is an inhibitory receptor for B-cell receptor (BCR) signalling, preferentially binds to alpha-2,6-linked sialic acid and mediates B-cell B-cell interactions. It plays a crucial role in activation and differentiation of the B-cell.

B cell receptor CD22 precursor; B lymphocyte cell adhesion molecule; BL CAM; CD 22; CD22 antigen; CD22 molecule; Lectin 2; Leu14; Lyb8; MGC130020; sialic acid binding Ig like lectin 2; SIGLEC 2; T cell surface antigen Leu 14