BI-6C9

BI-6C9 is a highly specific BH3 interacting domain (Bid) inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from mitochondrial apoptosis inducing factor (AIF) release and caspase-independent cell death in neurons[1].

Product Specifications

CAS Number

[791835-21-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Mitochondrial Metabolism

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bi-6c9.html

Purity

98.47

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(SC2=CC=C(N)C=C2)C=C1)CCCNS(=O)(C3=CC=C(OC)C=C3)=O

Molecular Formula

C23H25N3O4S2

Molecular Weight

471.59

Precautions

H302, H315, H319, H335

References & Citations

[1]Grohm J, et al. Bid mediates fission, membrane permeabilization and peri-nuclear accumulation of mitochondria as a prerequisite for oxidative neuronal cell death. Brain Behav Immun. 2010 Jul;24 (5) :831-8.