EGFR/HER2-IN-12

EGFR/HER2-IN-12 (compound 14b) is a dual inhibitor of EGFR and HER2 with 81% and 51% inhibition at 10 μM. The toxicity of EGFR/HER2-IN-12 to cancer cells A431 and MDA-MB-361 was not significant[1].

Product Specifications

CAS Number

[2237230-21-4]

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/egfr-her2-in-12.html

Solubility

10 mM in DMSO

Smiles

O=[N+]([O-])C1=CC=C(C2=CC3=C(NC4=CC=C(C(Cl)=C4)OC5=CC=CC(C)=C5)N=CN=C3S2)C=C1

Molecular Formula

C25H17ClN4O3S

Molecular Weight

488.95

References & Citations

[1]Milik SN, et al. Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitors. Eur J Med Chem. 2018 Jul 15;155:316-336.