4-Methylamino antipyrine

4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever[1][2][3]. 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak antiinflammatory properties[2].

Product Specifications

CAS Number

[519-98-2]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

COX; Drug Metabolite

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/4-methylamino-antipyrine.html

Purity

99.80

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1N(C2=CC=CC=C2)N(C)C(C)=C1NC

Molecular Formula

C12H15N3O

Molecular Weight

217.27

Precautions

H315, H319, H335

References & Citations

[1]Burmańczuk A, et al. Pharmacokinetic investigations of the marker active metabolites 4-methylamino-antipyrine and 4-amino-antipyrine after intramuscular injection of metamizole in healthy piglets. J Vet Pharmacol Ther. 2016 Dec;39 (6) :616-620.|[2]Ariza A, et al. Pyrazolones metabolites are relevant for identifying selective anaphylaxis to metamizole. Sci Rep. 2016 Mar 31;6:23845.|[3]Campos C1, et al. Regulation of cyclooxygenase activity by metamizol. Eur J Pharmacol. 1999 Aug 13;378 (3) :339-47.